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Moreover, we observed that APAP also leads to severe growth arrest in vitro, with a little detectable proliferation from 2 mM APAP upwards (Fig

The enzyme CSE catalyzes the synthesis of cysteine from cystathionine, and its promoter contains a binding site for Nrf2, and expression can be triggered by oxidative stress (199)

An investigation documented the process of sulfhydration of Keap1, which subsequently triggers the activation of Nrf2, which is the main regulator of the response to oxidative stress

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